Journal article
The Receptor Site and Mechanism of Action of Sodium Channel Blocker Insecticides*
Abstract
Sodium channels are excellent targets of both natural and synthetic insecticides with high insect selectivity. Indoxacarb, its active metabolite DCJW, and metaflumizone (MFZ) belong to a relatively new class of sodium channel blocker insecticides (SCBIs) with a mode of action distinct from all other sodium channel-targeting insecticides, including pyrethroids. Electroneutral SCBIs preferably bind to and trap sodium channels in the inactivated …
Authors
Zhang Y; Du Y; Jiang D; Behnke C; Nomura Y; Zhorov BS; Dong K
Journal
Journal of Biological Chemistry, Vol. 291, No. 38, pp. 20113–20124
Publisher
Elsevier
Publication Date
9 2016
DOI
10.1074/jbc.m116.742056
ISSN
0021-9258