Journal article
Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid
Abstract
Niflumic acid (NFA) is a member of the fenamate class of nonsteroidal anti-inflammatory drugs. This compound and its derivatives are used worldwide clinically for the relief of chronic and acute pain. NFA is also a commonly used blocker of voltage-gated chloride channels. Here we present evidence that NFA is an efficient blocker of chloride-permeable glycine receptors (GlyRs) with subunit heterogeneity of action. Using the whole-cell …
Authors
Maleeva G; Peiretti F; Zhorov BS; Bregestovski P
Journal
Frontiers in Molecular Neuroscience, Vol. 10, ,
Publisher
Frontiers
DOI
10.3389/fnmol.2017.00125
ISSN
1662-5099