Journal article
Effects of cortisol and estradiol on pituitary expression of proopiomelanocortin, prohormone convertase-1, prohormone convertase-2, and glucocorticoid receptor mRNA in fetal sheep
Abstract
We hypothesized that in the late-gestation sheep fetus there is an interaction between the prepartum rise in cortisol and the increase in placental estradiol production that allows expression of key components of the fetal hypothalamic-pituitary-adrenal (HPA) axis. Therefore, the goal of this study was to investigate the effects of cortisol on the fetal HPA axis in the presence and absence of increased placental estradiol production. We …
Authors
Holloway AC; Whittle WL; Challis JRG
Journal
Endocrine, Vol. 14, No. 3, pp. 343–348
Publisher
Springer Nature
Publication Date
April 2001
DOI
10.1385/endo:14:3:343
ISSN
1355-008X