Common Carotid Intima-Media Thickness Relates to Cardiovascular Events in Adults Aged <45 Years Academic Article uri icon

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abstract

  • Although atherosclerosis starts in early life, evidence on risk factors and atherosclerosis in individuals aged <45 years is scarce. Therefore, we studied the relationship between risk factors, common carotid intima-media thickness (CIMT), and first-time cardiovascular events in adults aged <45 years. Our study population consisted of 3067 adults aged <45 years free from symptomatic cardiovascular disease at baseline, derived from 6 cohorts that are part of the USE-IMT initiative, an individual participant data meta-analysis of general-population-based cohort studies evaluating CIMT measurements. Information on risk factors, CIMT measurements, and follow-up of the combined end point (first-time myocardial infarction or stroke) was obtained. We assessed the relationship between risk factors and CIMT and the relationship between CIMT and first-time myocardial infarction or stroke using a multivariable linear mixed-effects model and a Cox proportional-hazards model, respectively. During a follow-up of 16.3 years, 55 first-time myocardial infarctions or strokes occurred. Median CIMT was 0.63 mm. Of the risk factors under study, age, sex, diastolic blood pressure, body mass index, total cholesterol, and high-density lipoprotein cholesterol related to CIMT. Furthermore, CIMT related to first-time myocardial infarction or stroke with a hazard ratio of 1.40 per SD increase in CIMT, independent of risk factors (95% confidence interval, 1.11-1.76). CIMT may be a valuable marker for cardiovascular risk in adults aged <45 years who are not yet eligible for standard cardiovascular risk screening. This is especially relevant in those with an increased, unfavorable risk factor burden.

authors

  • Eikendal, Anouk LM
  • Groenewegen, Karlijn A
  • Anderson, Todd J
  • Britton, Annie R
  • Engström, Gunnar
  • Evans, Greg W
  • de Graaf, Jacqueline
  • Grobbee, Diederick E
  • Hedblad, Bo
  • Holewijn, Suzanne
  • Ikeda, Ai
  • Kitagawa, Kazuo
  • Kitamura, Akihiko
  • Lonn, Eva
  • Lorenz, Matthias W
  • Mathiesen, Ellisiv B
  • Nijpels, Giel
  • Dekker, Jacqueline M
  • Okazaki, Shuhei
  • O’Leary, Daniel H
  • Polak, Joseph F
  • Price, Jacqueline F
  • Robertson, Christine
  • Rembold, Christopher M
  • Rosvall, Maria
  • Rundek, Tatjana
  • Salonen, Jukka T
  • Sitzer, Matthias
  • Stehouwer, Coen DA
  • Hoefer, Imo E
  • Peters, Sanne AE
  • Bots, Michiel L
  • den Ruijter, Hester M

publication date

  • April 2015