Polyphosphate colocalizes with factor XII on platelet-bound fibrin and augments its plasminogen activator activity Journal Articles

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abstract

Key PointsPolyP significantly augments the plasminogen activator capacity of FXIIa. Platelet-bound fibrin acts as a reservoir for plasminogen, FXII(a), and polyP.

authors

Mitchell, Joanne L
Lionikiene, Ausra S
Georgiev, Georgi
Klemmer, Anja
Brain, Chelsea
Kim, Paul
Mutch, Nicola J

status

published

publication date

December 15, 2016

has subject area

1102 Cardiorespiratory Medicine and Haematology (FoR)
1103 Clinical Sciences (FoR)
1114 Paediatrics and Reproductive Medicine (FoR)
Blood Platelets (MeSH)
Complement C1 Inhibitor Protein (MeSH)
Factor XII (MeSH)
Fibrin (MeSH)
Glutamic Acid (MeSH)
HeLa Cells (MeSH)
Humans (MeSH)
Immunology (Science Metrix)
Lysine (MeSH)
Plasminogen (MeSH)
Polyphosphates (MeSH)
Proteins (MeSH)

published in

Blood Journal