Journal article
Pathogen inactivation by riboflavin and ultraviolet light illumination accelerates the red blood cell storage lesion and promotes eryptosis
Abstract
BACKGROUND: Pathogen reduction treatment using riboflavin and ultraviolet light illumination (Mirasol) effectively reduces the risk of transfusion-transmitted infections. This treatment is currently licensed for only platelets and plasma products, while its application to whole blood (WB) to generate pathogen-inactivated red blood cells (RBCs) is under development. RBC storage lesion, constituting numerous morphologic and biochemical changes, …
Authors
Qadri SM; Chen D; Schubert P; Perruzza DL; Bhakta V; Devine DV; Sheffield WP
Journal
Transfusion, Vol. 57, No. 3, pp. 661–673
Publisher
Wiley
Publication Date
3 2017
DOI
10.1111/trf.13959
ISSN
0041-1132