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Diverse Evolutionary Trajectories Characterize a...
Journal article

Diverse Evolutionary Trajectories Characterize a Community of RNA-Cleaving Deoxyribozymes: A Case Study into the Population Dynamics of In Vitro Selection

Abstract

Two parallel in vitro selections (denoted Selection A and Selection B) were conducted under different selection-pressure regimes, yielding a diverse community of RNA-cleaving deoxyribozymes. In Selection A, the reaction time was reduced four times (from 5 h to 5 s) over the course of 24 generations, while in Selection B the reaction time was maintained at 5 h for 30 rounds of selective amplification. Sequence alignment was conducted on more …

Authors

Schlosser K; Li Y

Journal

Journal of Molecular Evolution, Vol. 61, No. 2, pp. 192–206

Publisher

Springer Nature

Publication Date

August 2005

DOI

10.1007/s00239-004-0346-7

ISSN

0022-2844