Development and Validation of a Dietary Portfolio Score for use Among Hypercholesterolemic Individuals

Background The Dietary Portfolio (DP) significantly improves serum low‐density lipoprotein (LDL) profiles in hypercholesterolemic individuals. We aimed to develop and validate a diet score based on the DP. Methods Hypercholesterolemic individuals who participated in a 6‐month DP trial were included. Four dietary components (soy protein, viscous fiber, plant sterols, and nuts) were identified a priori and each scored between 0‐10 units; components were summated to create a DP‐score (DPS) ranging from 0‐40 units. Multivariate linear regression quantified DPS with continuous variables; logistic regression compared individuals with 蠅‐25% ΔLDL vs. those without. Results Median end‐study DPS was 14 (range: 0‐40, n=238). A 1‐unit increase in DPS or ΔDPS decreased ΔLDL by ‐0.036mmol/L (‐0.81%, p<0.001), Δdiastolic blood pressure by ‐0.093mmHg (p=0.017), and Δ10‐year CHD risk by ‐0.048 (p<0.001). The odds of achieving a ‐25% ΔLDL was 23.8 fold (95%CI: 7.40 to 76.7) greater when comparing the highest and lowest adherence groups (31‐40 units vs. 0‐10 units). Conclusions DPS and ΔDPS predict beneficial cardiometabolic risk profiles. Future research should relate the DPS to the incidence of stroke and CHD. Funding CIHR, Loblaw Brands ltd, Unilever, Solae, AFM Net