Journal article
A Large-Scale Genetic Analysis Reveals a Strong Contribution of the HLA Class II Region to Giant Cell Arteritis Susceptibility
Abstract
We conducted a large-scale genetic analysis on giant cell arteritis (GCA), a polygenic immune-mediated vasculitis. A case-control cohort, comprising 1,651 case subjects with GCA and 15,306 unrelated control subjects from six different countries of European ancestry, was genotyped by the Immunochip array. We also imputed HLA data with a previously validated imputation method to perform a more comprehensive analysis of this genomic region. The …
Authors
Carmona FD; Mackie SL; Martín J-E; Taylor JC; Vaglio A; Eyre S; Bossini-Castillo L; Castañeda S; Cid MC; Hernández-Rodríguez J
Journal
American Journal of Human Genetics, Vol. 96, No. 4, pp. 565–580
Publisher
Elsevier
Publication Date
April 2015
DOI
10.1016/j.ajhg.2015.02.009
ISSN
0002-9297