Journal article
Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies
Abstract
Laboratory animal studies are used in a wide range of human health related research areas, such as basic biomedical research, drug research, experimental surgery and environmental health. The results of these studies can be used to inform decisions regarding clinical research in humans, for example the decision to proceed to clinical trials. If the research question relates to potential harms with no expectation of benefit (e.g., toxicology), …
Authors
Hooijmans CR; de Vries RBM; Ritskes-Hoitinga M; Rovers MM; Leeflang MM; IntHout J; Wever KE; Hooft L; de Beer H; Kuijpers T
Journal
PLOS ONE, Vol. 13, No. 1,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0187271
ISSN
1932-6203