Conference
Endurance training attenuates loss of bone strength in the polymerase gamma mutator mouse model of aging
Abstract
A causal role for mtDNA mutagenesis in aging‐associated bone loss is supported by recent studies demonstrating that the polymerase gamma (PolG) mutator mouse, harbouring a proofreading‐deficient copy of PolG, exhibits a significant reduction in whole‐body bone mineral content and density. Physiological aging is accompanied by kyphosis, osteoporosis and an increased incidence of fractures. Anecdotal evidence from human and rodent studies …
Authors
Antolic A; Safdar A; Bourgeois JM; Hettinga BP; Wohl GR; Kujoth GC; Prolla TA; Tarnopolsky MA
Volume
24
Pagination
pp. 618.19-618.19
Publisher
Wiley
Publication Date
April 2010
DOI
10.1096/fasebj.24.1_supplement.618.19
Conference proceedings
The FASEB Journal
Issue
S1
ISSN
0892-6638