Journal article
Interaction of l‐Prolyl‐l‐Leucyl Glycinamide with Dopamine D2 Receptor: Evidence for Modulation of Agonist Affinity States in Bovine Striatal Membranes
Abstract
The role of the hypothalamic tripeptide L-prolyl-L-leucyl-glycinamide (PLG) in modulating the agonist binding to bovine striatal dopamine D2 receptor was investigated using a selective high-affinity agonist, n-propylnorapomorphine (NPA). PLG caused an enhancement in [3H]NPA binding in striatal membranes in a dose-dependent manner, the maximum effect being observed at 10(-7)-10(-6) M concentration of the tripeptide. The Scatchard analysis of …
Authors
Srivastava LK; Bajwa SB; Johnson RL; Mishra RK
Journal
Journal of Neurochemistry, Vol. 50, No. 3, pp. 960–968
Publisher
Wiley
Publication Date
3 1988
DOI
10.1111/j.1471-4159.1988.tb03005.x
ISSN
0022-3042