Journal article
Factors affecting solubilized dopamine-sensitive adenylate cyclase
Abstract
Bovine striatal adenylate cyclase was solubilized with sodium cholate and assayed for its responsiveness to a variety of agents. Magnesium ions (0-20 mM), guanylyl-imidodiphosphate (10-50 microM), and striatal lipids were effective in increasing enzyme activity. The adenylate cyclase could be stimulated by dopamine, and neuroleptic drugs inhibited the effect of dopamine (50 microM) with potencies that paralleled their clinical potencies. The …
Authors
Marshall AM; Ramwani J; Mishra RK
Journal
Biochemical Pharmacology, Vol. 32, No. 7, pp. 1237–1241
Publisher
Elsevier
Publication Date
4 1983
DOI
10.1016/0006-2952(83)90277-0
ISSN
0006-2952