Journal article
Neuroleptic Drug-Induced Dopamine Receptor Supersensitivity: Antagonism by L-Prolyl-L-Leucyl-Glycinamide
Abstract
An animal model of tardive dyskinesia was used to evaluate the potential antidyskinetic properties of the neuropeptide L-prolyl-L-leucyl-glycinamide (PLG). In rats, PLG administered concurrently with the neuroleptic drug haloperidol or chlorpromazine antagonized the enhancement of specific [3H]spiroperidol binding in the striatum that is associated with long-term neuroleptic treatment. The results are discussed in relation to a possible …
Authors
Chiu S; Paulose CS; Mishra RK
Journal
Science, Vol. 214, No. 4526, pp. 1261–1262
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
December 11, 1981
DOI
10.1126/science.6117947
ISSN
0036-8075