Journal article
Genotype-guided versus standard vitamin K antagonist dosing algorithms in patients initiating anticoagulation
Abstract
Variability in vitamin K antagonist (VKA) dosing is partially explained by genetic polymorphisms. We performed a meta-analysis to determine whether genotype-guided VKA dosing algorithms decrease a composite of death, thromboembolic events and major bleeding (primary outcome) and improve time in therapeutic range (TTR). We searched MEDLINE, EMBASE, CENTRAL, trial registries and conference proceedings for randomised trials comparing …
Authors
Belley-Cote EP; Hanif H; D'Aragon F; Eikelboom JW; Anderson JL; Borgman M; Jonas DE; Kimmel SE; Manolopoulos VG; Baranova E
Journal
Thrombosis and Haemostasis, Vol. 114, No. 04, pp. 768–777
Publisher
Thieme
Publication Date
2015
DOI
10.1160/th15-01-0071
ISSN
0340-6245