Prognostic impact of kinase-activating fusions and IKZF1 deletions in pediatric high-risk B-lineage acute lymphoblastic leukemia Academic Article uri icon

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abstract

  • Key Points Fifteen percent of NCI high-risk, Ph-negative, B-ALL patients harbored a kinase-activating fusion, and often associated with IKZF1 deletion. IKZF1 deletion represents an independent prognostic factor of poor outcomes, regardless of fusion-positivity.

authors

  • Tran, Thai Hoa
  • Harris, Marian H
  • Nguyen, Jonathan V
  • Blonquist, Traci M
  • Stevenson, Kristen E
  • Stonerock, Eileen
  • Asselin, Barbara L
  • Athale, Uma
  • Clavell, Luis A
  • Cole, Peter D
  • Kelly, Kara M
  • Laverdiere, Caroline
  • Leclerc, Jean-Marie
  • Michon, Bruno
  • Schorin, Marshall A
  • Welch, Jennifer JG
  • Reshmi, Shalini C
  • Neuberg, Donna S
  • Sallan, Stephen E
  • Loh, Mignon L
  • Silverman, Lewis B

publication date

  • March 13, 2018