Journal article
Identification of capsazepine as a novel inhibitor of system xc− and cancer-induced bone pain
Abstract
The cystine/glutamate antiporter has been implicated in a variety of cancers as a major mediator of redox homeostasis. The excess glutamate secreted by this transporter in aggressive cancer cells has been associated with cancer-induced bone pain (CIBP) from distal breast cancer metastases. High-throughput screening of small molecule inhibitors of glutamate release from breast cancer cells identified several potential compounds. One such …
Authors
Fazzari J; Balenko MD; Zacal N; Singh G
Journal
Journal of Pain Research, Vol. 10, No. 0, pp. 915–925
Publisher
Taylor & Francis
Publication Date
April 18, 2017
DOI
10.2147/jpr.s125045
ISSN
1178-7090