Chlorogenic acid, a coffee polyphenol and antioxidant, hastens clinical onset of disease but prolongs life span in the G93A mouse, an animal model of ALS, as compared with caffeine

The G93A mouse, an animal model of amyotrophic lateral sclerosis, exhibits elevated markers of oxidative stress (malondialdehyde, protein carbonyls) and a compensatory upregulation of antioxidant enzyme activity (Mn‐SOD, catalase) in the gastrocnemius , compared with wildtype control. We aimed to study the effects of chlorogenic acid (CHLA, an antioxidant) and caffeine (CAFN), both ingredients in coffee, on functional and disease outcomes. We …