Journal article
Modafinil reduces excessive somnolence and enhances mood in patients with myotonic dystrophy
Abstract
OBJECTIVE: To evaluate the potential of modafinil in reducing excessive daytime somnolence (EDS) and enhancing indexes of quality of life and mood in patients with myotonic dystrophy (DM).
METHODS: Forty patients with DM were randomized to receive modafinil and placebo for 14 days each, using a double-blind, cross-over design. Before and after each trial, subjects completed handgrip strength testing, spirometry, and quality-of-life measures …
Authors
MacDonald JR; Hill JD; Tarnopolsky MA
Journal
Neurology, Vol. 59, No. 12, pp. 1876–1880
Publisher
Wolters Kluwer
Publication Date
December 24, 2002
DOI
10.1212/01.wnl.0000037481.08283.51
ISSN
0028-3878
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
Activities of Daily LivingAdolescentAdultAffectBenzhydryl CompoundsCentral Nervous System StimulantsDose-Response Relationship, DrugDouble-Blind MethodFemaleForced Expiratory VolumeHand StrengthHumansMaleMiddle AgedModafinilMyotonic DystrophyNeurologic ExaminationProspective StudiesQuality of LifeSleep Stages