Conference
Reinventing the Wheel: Voluntary Running Promotes Mitochondrial Adaptations in mtDNA Mutator Mouse Model of Aging
Abstract
The role of mitochondrial abnormalities and mitochondrial DNA (mtDNA) mutagenesis has been extensively characterized in aging. A causal role for mtDNA mutagenesis in aging is supported by recent studies demonstrating that the polymerase gamma (PolG) mutator mouse, harbouring a proofreading‐deficient copy of PolG, exhibits an accelerated aging phenotype, systemic mitochondrial dysfunction, multisystem failure, and reduced lifespan. Longitudinal …
Authors
Stokl AJ; Safdar A; Hettinga BP; Ogborn DI; Kujoth GC; Prolla TA; Tarnopolsky MA
Volume
24
Pagination
pp. lb647-lb647
Publisher
Wiley
Publication Date
April 2010
DOI
10.1096/fasebj.24.1_supplement.lb647
Conference proceedings
The FASEB Journal
Issue
S1
ISSN
0892-6638