This chapter considers the question of whether there is a moral imperative to pursue disease eradication once we have the means to achieveit. It examines three arguments that support the case for eradication from an ethical perspective: (a) the duty to rescue, (b) the duty to future generations, and (c) the notion of disease eradication as a global public good. It concludes that where disease eradication is possible, ethical motivation offers compelling reasons to act that cannot be dismissed without incurring moral liability. Ethical considerations should thus be weighed in the balance of reasons that inform decisions about whether or not to pursue disease eradication.