Journal article
TGFβ and Smad3 link inflammation to progressive fibrosis
Abstract
Transient adenovirus-mediated gene transfer of active TGFβ1 (AdTGFβ1) induces severe and progressive fibrosis in rodent lung without apparent inflammation. Alternately, transfer of IL-1β (AdIL-1β), a proinflammatory cytokine, induces marked tissue injury and inflammation which develops into progressive fibrosis. This inflammation is associated with an increase in TGFβ1 concentrations in bronchoalveolar lavage (BAL) fluid. This apparent …
Authors
Gauldie J; Bonniaud P; Margetts P; Sime P; Ask K; Kolb M
Journal
International Congress Series, Vol. 1302, , pp. 103–113
Publisher
Elsevier
Publication Date
June 2007
DOI
10.1016/j.ics.2006.10.025
ISSN
0531-5131