Natural And Recombinant ANTI-IgE Autoantibodies

Since the first description of anti-IgE autoantibodies by Williams et al. in 19721, these antibodies have remained a much disputed subject. Most immunologists considered such natural autoantibodies as low affinity antibodies of no importance. Despite the fact that Manning et al. described only 4 years later that repeated injections of a rabbit anti-Ig antiserum to neonatal mice suppressed not only IgM but also IgG, IgA and IgE synthesis2, it …