Journal article
On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations
Abstract
Genetic predisposition to obesity presents a paradox: how do genetic variants with a detrimental impact on human health persist through evolutionary time? Numerous hypotheses, such as the thrifty genotype hypothesis, attempt to explain this phenomenon yet fail to provide a justification for the modern obesity epidemic. In this critical review, we appraise existing theories explaining the evolutionary origins of obesity and explore novel …
Authors
Qasim A; Turcotte M; de Souza RJ; Samaan MC; Champredon D; Dushoff J; Speakman JR; Meyre D
Journal
Obesity Reviews, Vol. 19, No. 2, pp. 121–149
Publisher
Wiley
Publication Date
February 2018
DOI
10.1111/obr.12625
ISSN
1467-7881