Journal article
Pre-existing immunity against swine-origin H1N1 influenza viruses in the general human population
Abstract
A major concern about the ongoing swine-origin H1N1 influenza virus (S-OIV) outbreak is that the virus may be so different from seasonal H1N1 that little immune protection exists in the human population. In this study, we examined the molecular basis for pre-existing immunity against S-OIV, namely the recognition of viral immune epitopes by T cells or B cells/antibodies that have been previously primed by circulating influenza strains. Using …
Authors
Greenbaum JA; Kotturi MF; Kim Y; Oseroff C; Vaughan K; Salimi N; Vita R; Ponomarenko J; Scheuermann RH; Sette A
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 48, pp. 20365–20370
Publisher
Proceedings of the National Academy of Sciences
Publication Date
12 2009
DOI
10.1073/pnas.0911580106
ISSN
0027-8424