Journal article
Overexpression of cyclin E messenger ribonucleic acid in nasopharyngeal carcinoma correlates with poor prognosis
Abstract
AIMS: S-phase kinase-associated protein 2 is required for the degradation of p27 protein, which is a negative regulator of cyclin E/cyclin-dependent kinase 2 complex. The present study examined the expression of cyclin E, S-phase kinase-associated protein 2 and p27 protein in nasopharyngeal carcinoma.
METHODS: Tissue from 35 cases of nasopharyngeal carcinoma and 10 normal nasopharyngeal tissue samples underwent reverse polymerase chain reaction …
Authors
Ko M-T; Su C-Y; Huang S-C; Chen C-H; Hwang C-F
Journal
The Journal of Laryngology and Otology, Vol. 123, No. 9, pp. 1021–1026
Publisher
Cambridge University Press (CUP)
Publication Date
September 2009
DOI
10.1017/s0022215109004848
ISSN
0022-2151
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdolescentAdultAgedAged, 80 and overCyclin ECyclin-Dependent Kinase Inhibitor p27FemaleGene Expression Regulation, NeoplasticHumansImmunohistochemistryMaleMiddle AgedNasopharyngeal NeoplasmsNeoplasm ProteinsPrognosisProspective StudiesRNA TransportS-Phase Kinase-Associated ProteinsSurvival AnalysisYoung Adult