Journal article
Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD
Abstract
BACKGROUND: IL10 receptor (IL10R) deficiency causes severe infantile-onset inflammatory bowel disease. Intact IL10R-dependent signals have been shown to be important for innate and adaptive immune cell functions in mice. We have previously reported a key role of IL10 in the generation and function of human anti-inflammatory macrophages. Independent of innate immune cell defects, the aim of the current study was to determine the role of IL10R …
Authors
Shouval DS; Konnikova L; Griffith AE; Wall SM; Biswas A; Werner L; Nunberg M; Kammermeier J; Goettel JA; Anand R
Journal
Inflammatory Bowel Diseases, Vol. 23, No. 11, pp. 1950–1961
Publisher
Oxford University Press (OUP)
Publication Date
November 2017
DOI
10.1097/mib.0000000000001270
ISSN
1078-0998