Journal article
Effects of inhaled fluticasone propionate on CTLA‐4‐positive CD4+CD25+ cells in induced sputum in mild asthmatics
Abstract
BACKGROUND AND OBJECTIVE: Cytotoxic T-lymphocyte antigen 4 (CTLA-4) signalling of regulatory T cells regulates mucosal lymphocyte tolerance and differentiation, and may therefore have a beneficial effect in allergic diseases such as asthma. The aim of this study was to evaluate the effects of fluticasone propionate (FP) on CD4+CD25+ T cell co-expression of CTLA-4 in the sputum of mild asthmatic subjects.
METHODS: Eleven mild, stable asthmatic …
Authors
KAWAYAMA T; KINOSHITA T; IMAOKA H; GAUVREAU GM; O'BYRNE PM; AIZAWA H
Journal
Respirology, Vol. 13, No. 7, pp. 1000–1007
Publisher
Wiley
Publication Date
August 2008
DOI
10.1111/j.1440-1843.2008.01381.x
ISSN
1323-7799
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Administration, InhalationAdultAndrostadienesAntigens, CDAsthmaBronchodilator AgentsCD4-Positive T-LymphocytesCTLA-4 AntigenCross-Over StudiesDose-Response Relationship, DrugDouble-Blind MethodEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryFluticasoneFollow-Up StudiesHumansInterleukin-2 Receptor alpha SubunitLymphocyte CountMaleSeverity of Illness IndexSputumYoung Adult