Journal article
Role of heme oxygenase-1 in the biogenesis of corpora amylacea
Abstract
Corpora amylacea (CA) are glycoproteinaceous inclusions that accumulate in the human brain during normal aging and to a greater extent in Alzheimer's disease. We previously demonstrated that, in cultured rat astroglia, cysteamine (CSH) upregulates heme oxygenase-1(HO-1) and promotes the transformation of normal mitochondria into CA-like inclusions. In the current study, primary cultures of neonatal rat astroglia were exposed to880 µM CSH for …
Authors
Sahlas DJ; Liberman A; Schipper HM
Journal
Biogerontology, Vol. 3, No. 4, pp. 223–231
Publisher
Springer Nature
Publication Date
7 2002
DOI
10.1023/a:1016223109601
ISSN
1389-5729