Intrasession and Intersession Repeatability of Diffusion Tensor Imaging in Healthy Human Liver Journal Articles uri icon

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  • Objective The aim of this study was to evaluate the effect of signal to noise ratio (SNR) and number of gradient directions (NGD) on intra- and intersession repeatability of liver diffusion tensor imaging (DTI) metrics. Methods At each of 3 liver DTI scan sessions, liver diffusion was assessed in 5 healthy volunteers using a 6-direction DTI scan performed 9 separate times (ie, number of signal averages [NSA]). In addition, 4 combinations of NSA and NGD were acquired (NSA/NGD = 1/30, 3/10, 3/12, and 5/6) to determine the combined effect to DTI metrics, which was based on intersubject variability and intrasession (V intra) and intersession (V inter) repeatability. Results Intersubject variability was less than 20%, whereas V intra and V inter repeatability were less than 5% and less than 10%, respectfully. V inter was not affected by the NGD used. Decreases in V inter(FA), V inter1), V inter(RD), and V inter(MD) were observed with increasing NSA, and hence SNR. Conclusion Increased SNR may improve intrasession and intersession repeatability of liver DTI metrics. Scan repeatability was not influenced by NGD.


  • Wong, Oi Lei
  • Leung, Thomas Wai Tong
  • Lo, Gladys Goh
  • Yuan, Jing
  • Li, Wing Wa
  • Noseworthy, Michael

publication date

  • July 2017