Physiological correlates of pulmonary function in children with cystic fibrosis Journal Articles uri icon

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abstract

  • SummaryRationaleAlthough peak aerobic capacity (VO2peak) has been linked to outcome in patients with cystic fibrosis (CF), measuring is time consuming, and requires expensive equipment and expertise that is not readily available in all centers. Other fitness parameters such as peak anaerobic power, measures of power and strength may be simpler to deliver in the clinic. The relationship between these measures and established outcomes such as forced expiratory volume in one second (FEV1) and peak aerobic power (VO2peak) in CF remains unclear. Therefore we evaluated (a) aerobic fitness, (b) anaerobic fitness, and (c) upper and lower body muscle strength to determine their relationship to FEV1 and VO2peak in children with CF.MethodsEighty‐two patients (7–18 years) with CF (40 female) from the CF clinic at The Hospital for Sick Children in Toronto performed a maximal incremental cycling test to exhaustion. Anaerobic power (W) for 10 and 30 sec cycling trials as well as vertical jump (VJ) and hand grip strength (HG) were compared to FEV1 and VO2peak.ResultsAbsolute VO2peak (R2 = 0.16, P < 0.001), anaerobic power (R2 = 0.21, P < 0.001), and hand grip strength (R2 = 0.10, P = 0.003) were significantly correlated to lung function whereas measures of explosive lower body strength (VJ) were not. Anaerobic power (R2 = 0.16, P = 0.001) and hand grip strength (R2 = 0.08, P = 0.01) were related to VO2peak. Vertical jump was correlated with VO2peak (R2 = 0.29, P < 0.001) but not FEV1.ConclusionsSimple fitness tests such as hand grip strength and anaerobic cycle tests may be useful indicators of lung health and fitness. Pediatr Pulmonol. 2014; 49:878–884. © 2013 Wiley Periodicals, Inc.

authors

  • Wells, Greg
  • Wilkes, Donna L
  • Schneiderman, Jane E
  • Thompson, Sara
  • Coates, Allan L
  • Ratjen, Felix

publication date

  • September 2014