Novel cascade ultrafiltration configuration for continuous, high-resolution protein–protein fractionation: a simulation study

High-resolution protein–protein fractionation is an important and expensive activity in the biotechnological industry. Ultrafiltration (UF), a membrane-based separation process which combines high throughput of product with ease of scale-up is widely used for protein desalting and concentration. In recent years, the potential for achieving high-resolution protein fractionation using ultrafiltration has been demonstrated. However, there has been …