Modeling and Optimization of Protein PEGylation

A PEGylated protein is prepared by conjugating polyethylene glycol (or PEG) with the protein, a process known as PEGylation. Most PEGylation processes lead to synthesis of different PEGylated forms of the protein, among which only one form is typically of interest. In this work, we propose a modeling and optimization-based approach for determining optimal operating conditions for protein PEGylation. To this end, a first-principles model is …