Journal article
Regulation of Oxygen Sensitivity in Adrenal Chromaffin Cells
Abstract
Adrenomedullary chromaffin cells (AMC) possess a direct hypoxia-sensing mechanism that promotes a vital catecholamine surge at birth. This mitochondria-dependent adaptive mechanism is suppressed postnatally as AMC acquire cholinergic innervation, and it is mediated by K+ channel inhibition, membrane depolarization, and voltage-gated Ca2+ entry. We hypothesized that nicotinic ACh receptor (AChR) activation might contribute to this postnatal loss …
Authors
Nurse CA; Buttigieg J; Brown S; Holloway AC
Journal
Annals of the New York Academy of Sciences, Vol. 1177, No. 1, pp. 132–139
Publisher
Wiley
Publication Date
10 2009
DOI
10.1111/j.1749-6632.2009.05031.x
ISSN
0077-8923