Journal article
Transport of epidermal growth factor in the stroke-injured brain
Abstract
Stroke is a neurological disorder that currently has no cure. Intrathecal delivery of growth factors, specifically recombinant human epidermal growth factor (rhEGF), stimulates endogenous neural precursor cells in the subventricular zone (SVZ) and promotes tissue regeneration in animal models of stroke. In this model, rhEGF is delivered with an invasive minipump/catheter system, which causes trauma to the brain. A less invasive strategy is to …
Authors
Wang Y; Cooke MJ; Lapitsky Y; Wylie RG; Sachewsky N; Corbett D; Morshead CM; Shoichet MS
Journal
Journal of Controlled Release, Vol. 149, No. 3, pp. 225–235
Publisher
Elsevier
Publication Date
February 2011
DOI
10.1016/j.jconrel.2010.10.022
ISSN
0168-3659