Conference
PLAG1 and USF2 Regulate Primitive Hematopoietic Expression of Musashi-2
Abstract
Abstract
The Musashi-2 (MSI2) RNA binding protein is now recognized as a key regulator of hematopoietic stem cells (HSCs). Its expression is most elevated in the primitive HSC compartment and progressively decreases with differentiation. In mouse models of CML, ectopic expression of MSI2 drives progression from the chronic to the blast crisis state while in the human context its aberrantly high expression correlates with more …
Authors
Belew MS; Rentas S; de Rooij L; Hope KJ
Volume
126
Publisher
American Society of Hematology
Publication Date
December 3, 2015
DOI
10.1182/blood.v126.23.3583.3583
Conference proceedings
Blood
Issue
23
ISSN
0006-4971