Polymorphic Regulation of Outer Membrane Lipid A Composition Journal Articles

abstract

• ABSTRACT The importance of the polymorphic-phase behavior of lipid A structural variations in determining their endotoxic activities has been recognized previously, but any potential role for lipid A polymorphism in controlling outer membrane structure and function has been largely ignored until now. In a recent article in mBio [7(5):e01532-16, https://doi.org/10.1128/mBio.01532-16], Katherine E. Bonnington and Meta J. Kuehn of Duke University’s Department of Biochemistry make a compelling case for considering how the molecular shapes of the various lipid A structural subtypes found in the outer membrane contribute to the process of outer membrane vesicle (OMV) formation.

authors

• Bishop, Russell

status

• published 

publication date

• December 30, 2016

has subject area

• 0605 Microbiology (FoR)
• Bacterial Outer Membrane Proteins (MeSH)
• Biological Transport (MeSH)
• Cell Membrane (MeSH)
• Humans (MeSH)
• Lipid A (MeSH)
• Membrane Lipids (MeSH)

published in

• mBio  Journal

keywords

• Bacterial Outer Membrane Proteins
• Biological Transport
• Cell Membrane
• Humans
• Lipid A
• Membrane Lipids

Digital Object Identifier (DOI)

• 10.1128/mbio.01903-16

start page

• e01903

end page

• e01916

volume

• 7

issue

• 6