Stability of Pathway‐Hemisphere Differences in the Auditory Event‐Related Potential (ERP) to Monaural Stimulation
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ABSTRACTThe evidence for ERP manifestations of contralateral dominance in the auditory pathways is not entirely compelling. The effect when found has involved either latency or amplitude of a variety of components obtained from averaged or subtraction waveforms. Also, the effect appears to have as much to do with hemisphere as pathway differences. The objectives of this experiment were to establish whether a specific ERP peak reflected contralateral dominance, to assess its long‐term stability, and to clarify the apparent pathway‐hemisphere interactions which result from monaural stimulation. Ten male subjects were tested on 6 occasions (generally weekly intervals). On each occasion, 76 monaural tones were presented while EEG was recorded at C2, P2, T3, and T4 referred to linked earlobes. P70, N120, and P200 peak amplitudes and latencies and N1–P2 amplitudes were examined. N120 amplitudes proved to be larger at the temporal site contralateral to the ear stimulated. This contralateral dominance effect was observed on all 6 occasions for right ear stimuli and on all but one occasion for left ear stimuli. N1–P2 amplitudes less reliably reflected contralateral dominance because possible hemisphere effects appeared with this measure. Methodological issues related to assessment of ERP contralateral dominance and to the variety of effects seen in the literature are discussed. The data are examined with reference to neurophysiological substrates thought to underlie auditory ERPs. Finally, the utility of a stable ERP phenomenon in assessing drug or pathology effects is evaluated.
