283 Suppression of SMAD-1 signaling pathway in mouse lung tissue remodelling by oncostatin M

IntroductionAbnormal remodeling of the extracellular matrix (ECM) in lung tissue marks the pathology and compromises lung function in diseases such as pulmonary fibrosis and severe asthma. Various cytokine networks, including TGF-beta and gp130 cytokines, have been shown to modulate the ECM. More recent work has suggested a protective role for bone morphogenetic proteins (BMP) in pulmonary fibrosis. We have previously shown that over-expression …