Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17 Academic Article uri icon

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abstract

  • Linkage analysis of 15 Utah kindreds demonstrated that a gene responsible for von Recklinghausen neurofibromatosis (NF) is located near the centromere on chromosome 17. The families also gave no evidence for heterogeneity, indicating that a significant proportion of NF cases are due to mutations at a single locus. Further genetic analysis can now refine this localization and may lead to the eventual identification and cloning of the defective gene responsible for this disorder.

authors

  • Waye, John
  • Barker, D
  • Wright, E
  • Nguyen, K
  • Cannon, L
  • Fain, P
  • Goldgar, D
  • Bishop, D
  • Carey, J
  • Baty, B
  • Kivlin, J
  • et, al

publication date

  • May 29, 1987