Journal article
Gene for von Recklinghausen Neurofibromatosis Is in the Pericentromeric Region of Chromosome 17
Abstract
Linkage analysis of 15 Utah kindreds demonstrated that a gene responsible for von Recklinghausen neurofibromatosis (NF) is located near the centromere on chromosome 17. The families also gave no evidence for heterogeneity, indicating that a significant proportion of NF cases are due to mutations at a single locus. Further genetic analysis can now refine this localization and may lead to the eventual identification and cloning of the defective …
Authors
Barker D; Wright E; Nguyen K; Cannon L; Fain P; Goldgar D; Bishop DT; Carey J; Baty B; Kivlin J
Journal
Science, Vol. 236, No. 4805, pp. 1100–1102
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
May 29, 1987
DOI
10.1126/science.3107130
ISSN
0036-8075