Gene for von Recklinghausen Neurofibromatosis Is in the Pericentromeric Region of Chromosome 17 Journal Articles uri icon

  •  
  • Overview
  •  
  • Research
  •  
  • Identity
  •  
  • Additional Document Info
  •  
  • View All
  •  

abstract

  • Linkage analysis of 15 Utah kindreds demonstrated that a gene responsible for von Recklinghausen neurofibromatosis (NF) is located near the centromere on chromosome 17. The families also gave no evidence for heterogeneity, indicating that a significant proportion of NF cases are due to mutations at a single locus. Further genetic analysis can now refine this localization and may lead to the eventual identification and cloning of the defective gene responsible for this disorder.

authors

  • Barker, D
  • Wright, E
  • Nguyen, K
  • Cannon, L
  • Fain, P
  • Goldgar, D
  • Bishop, DT
  • Carey, J
  • Baty, B
  • Kivlin, J
  • Willard, H
  • Waye, John
  • Greig, G
  • Leinwand, L
  • Nakamura, Y
  • O'Connell, P
  • Leppert, M
  • Lalouel, J-M
  • White, R
  • Skolnick, M

publication date

  • May 29, 1987