1788 QUANTITATIVE ASSESSMENT OF VENTILATION INDUCED PULMONARY EPITHELIAL INJURY IN THE NEWBORN PIGLET

To better understand the airway damage that occurs in BPD we performed the following study to establish and quantitate a model of sub-lethal airway injury in a newborn animal. Six piglets less than 2 days old were anaesthetized, intubated, and ventilated with dry pure oxygen for 2 hours with a pressure limited time cycled ventilator. Lungs were fixed by instillation at 50 cmH2O pressure. Four unintubated piglets served as controls (C). Light …