Understanding wet granulation in the kneading block of twin screw extruders

The adoption of twin screw granulation to pharmaceutical manufacturing requires detailed understanding of the process, with one notable area of influence being screw design. A kneading block is a common screw element that is used to compress the wet granular mass, seemingly controlling the particle size and fracture strength of an end product. The present study provides a detailed examination of how this screw element functions for the wet …