Journal article
“Rolling” phenomenon in twin screw granulation with controlled-release excipients
Abstract
The developed knowledge regarding use of twin screw granulators for continuous wet granulation has been primarily limited to immediate release formulations in the literature. The present study highlights an issue previously unreported for wet granulation with twin screw extruders when using formulations containing controlled-release (CR) excipients. Long (3-10 mm), twisted noodle-like granules can be produced in the presence of these excipients …
Authors
Thompson MR; O’Donnell KP
Journal
Drug Development and Industrial Pharmacy, Vol. 41, No. 3, pp. 482–492
Publisher
Taylor & Francis
Publication Date
March 4, 2015
DOI
10.3109/03639045.2013.879723
ISSN
0363-9045