Examining the mechanics of granulation with a hot melt binder in a twin-screw extruder

Hot melt granulation involves particle enlargement with a binder that is in its molten state during processing with accompanying solids. Fundamental studies of the technique have been presented for high shear mixers and fluidized bed systems in the literature but with the recent interest in twin screw extrusion machinery by the pharmaceutical industry for continuous granulation, further investigation was necessary to determine if similar …