UV‐enhanced Expression of a Reporter Gene is Induced at Lower UV Fluences in Transcription‐coupled Repair Deficient Compared to Normal Human Fibroblasts, and is Absent in SV40‐transformed Counterparts¶

UV irradiation enhances transcription of a number of cellular and viral genes. We have compared dose responses for alterations in expression from reporter constructs driven by the human and murine cytomegalovirus (CMV) immediate early (IE) promoters in cells from patients with deficiencies in nucleotide excision repair (complementation groups of xeroderma pigmentosum and Cockayne syndrome) following UV exposure, or infection with UV‐damaged …