Guar gum and resistant starch consumption increases interleukin‐10 (IL‐10) abundance in the colon of pigs fed a high‐fat diet

This study was conducted to examine colonic abundances of anti‐inflammatory cytokine interleukin 10 (IL‐10) and pro‐inflammatory cytokines tumor necrosis factor‐alpha (TNF‐α) and interleukin‐6 (IL‐6) in pigs fed a high‐fat basal diet supplemented with 15% guar gum and resistant starch. A total of 24 Yorkshire grower barrows were assigned into a high‐fat basal diet as the control and two basal diets supplemented with 15% guar gum and retrograded high amylose cornstarch, i.e., resistant starch, according to a randomized block design for 4 weeks. Compared with the control group, guar gum and resistant starch consumption at 15% increased (P<0.05) colonic IL‐10 abundance. However, there was no difference (P>0.05) in colonic IL‐10 abundance between the 15%‐guar gum and the 15%‐resistant starch groups. Furthermore, the consumption of guar gum and resistant starch did not affect (P>0.05) colonic abundances of TNF‐α and IL‐6. We conclude that consumption of guar gum and resistant starch supplemented in a high‐fat basal diet may protect the colon from developing inflammation by enhancing IL‐10 abundance. Supported by OMAFRA of Canada.

Guar gum and resistant starch consumption increases interleukin‐10 (IL‐10) abundance in the colon of pigs fed a high‐fat diet Conferences