Guar gum and resistant starch consumption increases interleukin‐10 (IL‐10) abundance in the colon of pigs fed a high‐fat diet

This study was conducted to examine colonic abundances of anti‐inflammatory cytokine interleukin 10 (IL‐10) and pro‐inflammatory cytokines tumor necrosis factor‐alpha (TNF‐α) and interleukin‐6 (IL‐6) in pigs fed a high‐fat basal diet supplemented with 15% guar gum and resistant starch. A total of 24 Yorkshire grower barrows were assigned into a high‐fat basal diet as the control and two basal diets supplemented with 15% guar gum and retrograded high amylose cornstarch, i.e., resistant starch, according to a randomized block design for 4 weeks. Compared with the control group, guar gum and resistant starch consumption at 15% increased ( P <0.05) colonic IL‐10 abundance. However, there was no difference ( P >0.05) in colonic IL‐10 abundance between the 15%‐guar gum and the 15%‐resistant starch groups. Furthermore, the consumption of guar gum and resistant starch did not affect ( P >0.05) colonic abundances of TNF‐α and IL‐6. We conclude that consumption of guar gum and resistant starch supplemented in a high‐fat basal diet may protect the colon from developing inflammation by enhancing IL‐10 abundance. Supported by OMAFRA of Canada.