Dependence of albumin–fibrinogen simple and competitive adsorption on surface properties of biomaterials

Abstract Adsorption of fibrinogen and albumin from solutions of the proteins singly and in mixtures was studied. A variety of surfaces with varying degrees of hydrophilicity and thrombogenicity was investigated. Adsorption behavior shows a strong dependence on surface properties. All surfaces show a preference for fibrinogen, and the degree of preference appears to correlate with thrombogenic tendency and platelet reactivity.