Stochastic Lattice Model for Bone Remodeling and Aging Academic Article uri icon

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abstract

  • We investigate the remodeling process of trabecular bone inside a human vertebral body using a stochastic lattice model, in which the ability of living bone to adapt to mechanical stimuli is incorporated. Our simulations show the emergence of a networklike structure similar to real trabecular bone. With time, the bone volume fraction reaches a steady state. The microstructure, however, coarsens with a typical length in the system following a power law. The simulation results suggest that a coarsening of the trabecular structure should occur as a natural aging phenomenon, not related to disease.

authors

  • Weinkamer, Richard
  • Hartmann, Markus A
  • Brechet, Yves
  • Fratzl, Peter

publication date

  • November 26, 2004