Abstract LB-166: Cabozantinib (cabo) + abiraterone (abi) combination therapy in castration resistant prostate cancer (CRPC): preclinical evaluation and interim results of an investigator-sponsored phase 1 clinical study.

Abstract Introduction: Abi (CYP17A1 and lyase inhibitor) and cabo (multi-targeted receptor tyrosine kinase inhibitor including MET and VEGFR2) have complementary mechanisms of action and both have significant single agent activity in CRPC. Cabo decreases evidence of skeletal disease on 99mTc bone scans to a marked degree. Rationale exists for cabo to enhance abi efficacy.