Journal article
Characterization of the Supernumerary Chromosome in Cat Eye Syndrome
Abstract
Most individuals with cat eye syndrome (CES) have a supernumerary bisatellited chromosome which, on the basis of cytogenetic evidence, has been reported to originate from either chromosome 13 or 22. To resolve this question, a single-copy DNA probe, D22S9, was isolated and localized to 22q11 by in situ hybridization to metaphase chromosomes. The number of copies of this sequence was determined in CES patients by means of Southern blots and …
Authors
McDermid HE; Duncan AMV; Brasch KR; Holden JJA; Magenis E; Sheehy R; Burn J; Kardon N; Noel B; Schinzel A
Journal
Science, Vol. 232, No. 4750, pp. 646–648
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
May 2, 1986
DOI
10.1126/science.3961499
ISSN
0036-8075